Title of article
A simple and convenient method for synthesis of new aminonaphthoquinones derived from lawsone by catalytic multicomponent Mannich reaction
Author/Authors
Fiorot، نويسنده , , Rodolfo G. and Allochio Filho، نويسنده , , Joمo F. and Pereira، نويسنده , , Thieres M.C. and Lacerda Jr.، نويسنده , , Valdemar and dos Santos، نويسنده , , Reginaldo B. and Romمo، نويسنده , , Wanderson and Greco، نويسنده , , Sandro J.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
4373
To page
4377
Abstract
A clean, efficient and facile one-pot protocol was developed for the synthesis of a series of new aminonaphthoquinones derived from 2-hydroxy-1,4-naphthoquinone (lawsone) by three-component Mannich reaction using catalytic amount of p-TsOH in CH3CN, at room temperature. At the present work, we improved the yield and significantly reduced the reaction time for several Mannich reactions with different amine and aromatic aldehydes using a non-expensive, mild catalyst and suitable solvent.
Keywords
multicomponent reaction , Catalytic Mannich reaction , Lawsone
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890283
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