Title of article :
A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides
Author/Authors :
Goldberg، نويسنده , , Kristin and Clarke، نويسنده , , David S. and Scott، نويسنده , , James S.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
A safe and facile method for the formation of 3-trifluoromethyl-5-amino-1,2,4-oxadiazoles, via a reversed addition of hydroxylamine to cyanamides, is reported. This two-pot procedure is suitable to scale-up and avoids the hazards associated with trifluoromethyl amidoxime synthesis.
Keywords :
3-Trifluoromethyl-1 , 2 , 4-oxadiazoles , N-Boc-hydroxylamine , Cyanamides , 1 , 4-oxadiazoles , 2
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
