Title of article
Design, synthesis, and evaluation, derivatives of the fat-accumulation inhibitor ternatin: toward ternatin molecular probes
Author/Authors
Kawazoe، نويسنده , , Yoshinori and Tanaka، نويسنده , , Yoko and Omura، نويسنده , , Sachikazu and Uemura، نويسنده , , Daisuke، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
4445
To page
4447
Abstract
Ternatin, a cyclic heptapeptide derived from mushroom, strongly inhibits fat accumulation in 3T3-L1 adipocytes. However, its mechanism of action remains unclear. In this Letter, we designed, synthesized, and evaluated its derivatives for use as molecular probes to isolate its target protein. Finally, we successfully established a pair of ternatin molecular probes.
Keywords
cyclic peptide , 3T3-L1 cell , Ternatin , Molecular probe , Fat accumulation
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890321
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