Synthesis of 4-aryl-2,3-dihydropyrroles via Rh-catalyzed intramolecular hydroamino-methylation reaction

The rhodium-catalyzed intramolecular hydroaminomethylation reaction, generating 4-aryl-2,3-dihydropyrroles, has been developed. Triphenylphosphine has been proved to be the excellent ligand to prepare the dihydropyrrole derivatives in up to 99% yield. This procedure provides an efficient and simple alternative route to synthesize 4-aryl-2,3-dihydropyrrole derivatives only in one step.