Author/Authors :
Hahn، نويسنده , , Dongyup and Chin، نويسنده , , Jungwook and Kim، نويسنده , , Hiyoung and Yang، نويسنده , , Inho and Won، نويسنده , , Dong Hwan and Ekins، نويسنده , , Merrick and Choi، نويسنده , , Hyukjae and Nam، نويسنده , , Sang-Jip and Kang، نويسنده , , Heonjoong Kang، نويسنده ,
Abstract :
One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2–5) as well as two isolation artifacts (6–7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50 values of 18 and 30 μg/mL, respectively.
Keywords :
PPAR? , Ircinia sp. , sesquiterpenoids , Sponge , OBESITY
