Title of article
Sesquiterpenoids with PPARδ agonistic effect from a Korean marine sponge Ircinia sp.
Author/Authors
Hahn، نويسنده , , Dongyup and Chin، نويسنده , , Jungwook and Kim، نويسنده , , Hiyoung and Yang، نويسنده , , Inho and Won، نويسنده , , Dong Hwan and Ekins، نويسنده , , Merrick and Choi، نويسنده , , Hyukjae and Nam، نويسنده , , Sang-Jip and Kang، نويسنده , , Heonjoong Kang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
4716
To page
4719
Abstract
One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2–5) as well as two isolation artifacts (6–7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPARδ agonistic activities, with EC50 values of 18 and 30 μg/mL, respectively.
Keywords
PPAR? , Ircinia sp. , sesquiterpenoids , Sponge , OBESITY
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890420
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