Title of article :
Synthesis of tetrahedral diarylheptanoid ent-diospongin A and epimer-diospongin B by employing Julia–Kocienski olefination
Author/Authors :
Meruva، نويسنده , , Suresh Babu and Mekala، نويسنده , , Ramamohan and Raghunadh، نويسنده , , Akula and Raghavendra Rao، نويسنده , , K. and Dahanukar، نويسنده , , Vilas H. and Pratap، نويسنده , , T.V. and Syam Kumar، نويسنده , , U.K. and Dubey، نويسنده , , P.K.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2014
Abstract :
Total synthesis of ent-diospongin A and epimer-diospongin B has been accomplished in good yield with high optical purity. The key steps of diospongin synthesis involve Julia–Kocienski olefination, Weinreb amide formation, Grignard reaction, reduction, acetonide deprotection, Lewis acid catalyzed cyclization, and Wacker oxidation.
Keywords :
Julia–Kocienski olefination , Wacker oxidation , Diaryl heptanoids , Diospongin A & , B , IPDO IPM-00405 , Weinreb amide
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
