Author/Authors :
Nguyen Le، نويسنده , , Thanh and De Borggraeve، نويسنده , , Wim M. and Grellier، نويسنده , , Philippe and Pham، نويسنده , , Van Cuong and Dehaen، نويسنده , , Wim and Nguyen، نويسنده , , Van Hung، نويسنده ,
Abstract :
A series of new 11-aza-artemisinin derivatives were prepared from 11-aza-artemisinin using the Ugi reaction. An antimalarial activity evaluation against the FcB1 strain indicated that compounds 7, 10, and 16 had very strong inhibitory activity. Comparison of the activity among the synthetic derivatives of this series revealed that the length of the side chain R group on the amide nitrogen could be critical for their antimalarial properties.
Keywords :
artemisinin , Aza-artemisinin , Ugi reaction , antimalarial , Synthesis
