Title of article
Design, synthesis, and biological evaluation of indolylidinepyrazolones as potential anti-bacterial agents
Author/Authors
Indrasena، نويسنده , , A. and Riyaz، نويسنده , , Sd. and Mallipeddi، نويسنده , , Prema L. and Padmaja، نويسنده , , P. and Sridhar، نويسنده , , B. and Dubey، نويسنده , , P.K.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
5
From page
5014
To page
5018
Abstract
A series of indolylidinepyrazolones were synthesized using a simple, green, and effective route and evaluated as anti-bacterial agents. The compounds were further studied via structure-guided docking study. One of the compounds exhibiting H-bonding interactions with conserved residue Arg144 turned out to be the most potent compound of the series. The minimum inhibitory concentration values ranged from 50 to 25 μg/mL against Staphylococcus aureus in their anti microbial evaluation.
Keywords
Pyrazolone , Knoevenagel condensation , DNA Gyrase inhibitors , Indole-3-carboxaldehyde , DMF-DMA
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890559
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