Author/Authors :
Dang، نويسنده , , Qun and Zhang، نويسنده , , Zhibo and Bai، نويسنده , , Yunfeng and Sun، نويسنده , , Ruijun and Yin، نويسنده , , Jie and Chen، نويسنده , , Tongqian and Bogen، نويسنده , , Stephane and Girijavallabhan، نويسنده , , Vinay and Olsen، نويسنده , , David B. and Meinke، نويسنده , , Peter T.، نويسنده ,
Abstract :
To discover novel nucleosides as potential anti-HCV agents, nucleosides with a 1′,2′-β-lactam moiety were designed as a hybrid scaffold of MK-608 and GS-6620. Synthetic strategies were successfully developed to prepare two series of C-nucleosides with a 1′,2′-β-lactam moiety: a 7-deaza-purine C-nucleoside analog 11 was prepared in 10 steps with an overall yield of 3.7%; a purine C-nucleoside analog 22 was prepared in 9 steps with an overall yield of 9.7%.
Keywords :
Prodrugs , ?-Lactam , nucleoside , HCV NS5B , C-nucleoside
