Author/Authors :
Zhang، نويسنده , , Bo and Liu، نويسنده , , Bin and Chen، نويسنده , , Jianbin and Wang، نويسنده , , Jiehui and Liu، نويسنده , , Miaochang، نويسنده ,
Abstract :
An I2-promoted 3-formylation of free (N–H) and N-substituted indoles with tetramethylethylenediamine (TMEDA) and H2O as the carbonyl source is achieved, providing 3-formylindole in moderate to excellent yields with good functional group tolerance. This procedure represents an exceedingly attractive alternative to the traditional formylation methods.
Keywords :
iminium ion , Tertiary amine , 3-formylindole , iodine
