Title of article
A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake® exploiting an optimized Hofmann-type rearrangement
Author/Authors
Balaev، نويسنده , , A.N. and Okhmanovich، نويسنده , , K.A. and Osipov، نويسنده , , V.N.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
5745
To page
5747
Abstract
An unusual five-step synthesis of H-β-Ala-Pro-DabNHBz diacetate (a muscular nicotinic acetylcholine receptor antagonist) has been delineated through Hofmann-type rearrangement as a final step to build the target skeleton. The synthesis has been carried out using a protecting group free strategy and employed readily available reagents as the starting materials.
Keywords
Peptides , Tripeptide , Syn-Ake® , mnAChR antagonist , Hofmann-type rearrangement
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890905
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