Title of article
Sodium borohydride mediated reduction of N-Boc protected purines and applications in the synthesis of 7-alkyladenines and tetrahydro[1,4]diazepino-[1,2,3-gh]purines
Author/Authors
Aarhus، نويسنده , , Thomas Ihle and Fritze، نويسنده , , Urs Fabian and Hennum، نويسنده , , Martin A. Gundersen، نويسنده , , Lise-Lotte، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
5748
To page
5750
Abstract
Electron deficient purines can be reduced to 7,8-dihydropurines when treated with cheap and easy-to-handle sodium borohydride in methanol. The dihydropurine formed by reduction of tris-Boc-protected adenine is a useful intermediate in efficient syntheses of 7-alkyladenines and tetrahydro[1,4]diazepino[1,2,3-gh]purines.
Keywords
Reduction , Purine , Michael addition , Tetrahydrodiazepinopurine , Alkylation
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890907
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