Title of article
Fungi mediated production and practical purification of (R)-(−)-3-quinuclidinol
Author/Authors
Kolet، نويسنده , , Swati P. and Jadhav، نويسنده , , Dipesh D. and Priyadarshini، نويسنده , , Balaraman and Swarge، نويسنده , , Bhagyashree N. and Thulasiram، نويسنده , , Hirekodathakallu V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
5911
To page
5914
Abstract
A fungal system belonging to Mucoraceae family (Mucor piriformis) was explored for the asymmetric reduction of a prochiral ketone, 3-quinuclidinone (I) in an efficient manner to produce an important pharmaceutical precursor (R)-(−)-3-quinuclidinol (II) with ∼96% enantiomeric excess. The efficiency of the process was improved by developing a cation exchange resin (Amberlite IR-120) which assisted the purification of water soluble metabolite II from fermentation media.
Keywords
Mucor piriformis , ion exchange resin , Amberlite IR-120 , (R)-(?)-3-Quinuclidinol , biotransformation
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890972
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