Author/Authors :
Xiao، نويسنده , , Shi-Ji and Lei، نويسنده , , Xin-Xiang and Xia، نويسنده , , Bing and Xu، نويسنده , , Dan-Qing and Xiao، نويسنده , , Hongping and Xu، نويسنده , , Hongxi and Chen، نويسنده , , Shin-Fang and Ding، نويسنده , , Li-Sheng and Zhou، نويسنده , , Yan، نويسنده ,
Abstract :
Two novel lignans, gymnothespirolignans A (1) and B (2), possessing a rare polycyclic spiro skeleton, were isolated from the endemic plant of Gymnotheca involucrata Pei. Their structures were determined by spectroscopic evidences and the absolute configurations were confirmed by single crystal X-ray diffraction analysis. Compounds 1 and 2 showed promising antiviral activities against RSV with an IC50 value of 31.87 and 17.51 μM, respectively.
