Title of article
Direct access to 2-aminopyrazolo[1,5-a]pyridines via N-amination/cyclization reactions of 2-pyridineacetonitriles
Author/Authors
Nishigaya، نويسنده , , Yosuke and Umei، نويسنده , , Kentaro and Yamamoto، نويسنده , , Eri and Kohno، نويسنده , , Yasushi and Seto، نويسنده , , Shigeki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
4
From page
5963
To page
5966
Abstract
We describe the straightforward synthesis of 6-substituted-2-aminopyrazolo[1,5-a]pyridines from 2-pyridineacetonitriles by N-amination with O-(mesitylsulfonyl)hydroxylamine and subsequent base-promoted cyclization. This N-amination/intramolecular cyclization reaction allows access to a variety of 6-substituted-2-aminopyrazolo[1,5-a]pyridines in a one-pot procedure, in moderate to good yields.
Keywords
2-Pyridineacetonitrile , N-amination/cyclization , Medicinal chemistry programs , 5-a]pyridine
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1890994
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