Author/Authors :
Garud، نويسنده , , Dinesh R. and Jadhav، نويسنده , , Amol R. and Lahore، نويسنده , , Santosh V. and Kahar، نويسنده , , Nilesh M. and Joshi، نويسنده , , Rohini R. and Joshi، نويسنده , , Ramesh A. and Koketsu، نويسنده , , Mamoru، نويسنده ,
Abstract :
The regioselective iodocyclization reaction of allene–thioureas is described, for the first time, for the synthesis of bicyclic β-lactams. The substitution at the allenyl part heavily influenced the iodocyclization reaction. The iodocyclization reaction of the unsubstituted allene–thioureas afforded six-membered 3-thia-1-dethiacephems whereas, the substituted allene–thiourea afforded seven-membered thiazepines along with five-membered isopenams.
Keywords :
iodocyclization , Thiourea , regioselective , Allene , ?-Lactams
