Author/Authors :
Witkowska، نويسنده , , Ewa and Kubik، نويسنده , , Karolina and Krosnicka، نويسنده , , Jolanta and Grabowska، نويسنده , , Karolina and Niescioruk، نويسنده , , Anna and Wilenska، نويسنده , , Beata and Misicka، نويسنده , , Aleksandra، نويسنده ,
Abstract :
The guanidinylation of a peptide chain on a polymeric support under microwave conditions using derivatives of thioureas—S-alkylisothioureas, pyrazole-carboxamidine, and guanidine as guanidinylating reagents is described. The best results are obtained with N,N′-di-Z-S-methylisothiourea and N,N′-di-Z(2-Cl)-S-methylisothiourea. It is found that guanidinylation with reagents containing Boc groups is accompanied by side reactions.
Keywords :
Guanidinylation , Solid phase peptide synthesis , microwave irradiation , Side reactions
