Total synthesis of bioactive drimane–epoxyquinol hybrid natural products: macrophorin A, 4′-oxomacrophorin A, and 1′-epi-craterellin A

Total synthesis of novel hybrid natural products, merosesquiterpenoids macrophorin A, 4′-oxomacrophorin A, and 1′-epi-craterellin A has been accomplished following a general strategy based on a sacrificial Diels–Alder–retroDiels–Alder approach to control regio- and stereoselectivity.