Title of article
Synthesis of unnatural 3′-phospha-2′-deoxyfuranose nucleoside analogues
Author/Authors
Dayde، نويسنده , , Bénédicte and Pierra، نويسنده , , Claire and Gosselin، نويسنده , , Gilles and Surleraux، نويسنده , , Dominique and Ilagouma، نويسنده , , Amadou Tidjani and Volle، نويسنده , , Jean-Noël and Virieux، نويسنده , , David and Pirat، نويسنده , , Jean-Luc، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
6328
To page
6330
Abstract
This Letter describes the synthesis of racemic analogues of unnatural 2′-deoxy nucleoside with a phosphorus atom replacing the carbon atom in the 3′-position. A seven-step sequence was developed in racemic series to afford unnatural 3′-phospha-2′-deoxyfuranose nucleosides. The phospha nucleoside analogues were tested against HCV, but did not show any antiviral activity at a 10 μM maximum concentration used for the inhibition assays of analogues 2-T, 2-C and 4-Tα.
Keywords
Deoxy nucleosides analogues , Pudovik reaction , P-alkylation reaction , Radical deiodination
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891182
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