Author/Authors :
Chavan، نويسنده , , Subhash P. and Khairnar، نويسنده , , Lalit B. and Chavan، نويسنده , , Prakash N. and Dumare، نويسنده , , Nilesh B. and Kalbhor، نويسنده , , Dinesh B. and Gonnade، نويسنده , , Rajesh G.، نويسنده ,
Abstract :
The efficient and practical formal syntheses of both enantiomers of cis 3-hydroxypipecolic acid were accomplished from cis aziridine-2-carboxylate as the common synthetic precursor. The key steps involved are stereo and regioselective aziridine ring opening, reductive cyclization and selective N-debenzylation over O-debenzylation reactions.
Keywords :
piperidine alkaloids , aziridine ring opening , 3-Hydroxypipecolic acid , Aziridine-2-carboxylate , Selective debenzylation
