One-pot synthesis of α-fluoro-β-amino acid and indole spiro-derivatives via CN bond cleavage/formation

In this Letter, the α-fluoro-β-amino acid directives were elegantly generated via a novel strategy of the nucleophilic addition of arynes and aziridines. CN bonds were successfully constructed with high efficiency. With the utilization of TABF hydrate as the fluorinated reagent, fluorine atom could be assembled into the target molecule selectively. Interestingly, under another condition, unexpected indole spiro-derivatives could be achieved successfully.