Author/Authors :
Li، نويسنده , , Rui-Juan and Zhao، نويسنده , , Yu and Tokuda، نويسنده , , Harukuni and Yang Mou، نويسنده , , Xiao-Ming and Wang، نويسنده , , Yue-Hu and Shi، نويسنده , , Qian and Morris-Natschke، نويسنده , , Susan L. and Lou، نويسنده , , Hong-Xiang and Lee، نويسنده , , Kuo-Hsiung، نويسنده ,
Abstract :
A new and efficient total synthesis has been developed to obtain plagiochin G (22), a macrocyclic bisbibenzyl, and four derivatives. The key 16-membered ring containing biphenyl ether and biaryl units was closed via an intramolecular SNAr reaction. All synthesized macrocyclic bisbibenzyls inhibited Epstein–Barr virus early antigen (EBV-EA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and, thus, are potential cancer chemopreventive agents.
Keywords :
Bisbibenzyls , Plagiochin G , intramolecular SNAr reaction , Epstein–Barr virus early antigen (EBV-EA) , Cancer chemopreventive agents
