Title of article
New naphthoquinone and monoterpenoid from Plumbago zeylanica
Author/Authors
Ohira، نويسنده , , Susumu and Yokogawa، نويسنده , , Yoshiaki and Tsuji، نويسنده , , Shinji and Mitsui، نويسنده , , Taichi and Fukukawa، نويسنده , , Tatsuhiko and Hayashi، نويسنده , , Ken-ichiro and Kuboki، نويسنده , , Atsuhito and Matsuura، نويسنده , , Nobuyasu and Iinuma، نويسنده , , Munekazu and Nozaki، نويسنده , , Hiroshi، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
6554
To page
6556
Abstract
New naphthoquinone 2 and new monoterpenoid 3 were isolated from the stems of Plumbago zeylanica, and their structures were determined on the basis of 2D NMR spectroscopy. Absolute configuration of 3 was established by synthesis of its enantiomer. The new naphthoquinone 2 showed potent inhibitory activity against nuclear factor κB (NF-κB), equivalent to that of parthenolide, a known potent inhibitor of NF-κB.
Keywords
absolute configuration , Plumbago zeylanica , Nuclear factor ?B , naphthoquinone , chiral synthesis , Monoterpenoid
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891292
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