Author/Authors :
Choi، نويسنده , , Minho and Won، نويسنده , , Sun-Woo and Jo، نويسنده , , Hyeju and Viji، نويسنده , , Mayavan and Seo، نويسنده , , Seung Yong and Lee، نويسنده , , Yeon-Ju and Lee، نويسنده , , Hyi-Seung and Lee، نويسنده , , Heesoon and Hong، نويسنده , , Jin Tae and Kwak، نويسنده , , Young Shin and Jung، نويسنده , , Jae-Kyung، نويسنده ,
Abstract :
A facile and efficient method has been developed for the synthesis of novel thiazolyl carboxamide derivatives by direct reaction of the corresponding esters and 2-aminothiazole. Treatment of 2-aminothiozole with various carboxylic esters in the presence of t-butylmagnesium chloride provides the biologically significant thiazolyl carboxamide derivatives in good to excellent yields.
Keywords :
2-Aminothiazole , amide , t-Butylmagnesium chloride , Transamidation , Carboxamide
