Title of article
Step-economy etherification of acylated alcohols
Author/Authors
Xu، نويسنده , , Hua-Dong and Xu، نويسنده , , Ke and Zheng، نويسنده , , Qing and He، نويسنده , , Wei-Jie and Shen، نويسنده , , Meihua and Hu، نويسنده , , Wen-Hao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2014
Pages
3
From page
6836
To page
6838
Abstract
An efficient and convenient protocol has been developed for ether bond formation in mild conditions. A mixture of primary/secondary ester and allylic/benzylic halide in tetrahydrofuran was treated with KOtBu at room temperature to give ether in high yield. This step economic method enabled direct alkylation of the acyl group masked O-nucleophiles. Application of this method in carbohydrate synthesis was feasible and chemo-selectivity can be achieved.
Keywords
Step economy , Ether , O-alkylation , etherification , potassium tert-butoxide
Journal title
Tetrahedron Letters
Serial Year
2014
Journal title
Tetrahedron Letters
Record number
1891399
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