Author/Authors :
Fortuin، نويسنده , , F.David and Vale، نويسنده , , Peter and Losordo، نويسنده , , Douglas W. and Symes، نويسنده , , James and DeLaria، نويسنده , , Giacomo A. and Tyner، نويسنده , , J.Jeffrey and Schaer، نويسنده , , Gary L. and March، نويسنده , , Robert and Snell، نويسنده , , R.Jeffrey and Henry، نويسنده , , Timothy D. and Van Camp، نويسنده , , Joseph W. Lopez، نويسنده , , John J. and Richenbache، نويسنده ,
Abstract :
This phase I open label, dose-escalating study shows that gene transfer of vascular endothelial growth factor-2 naked deoxyribonucleic acid by direct myocardial injection by way of thoracotomy in patients with Canadian Cardiovascular Society class 3 or 4 angina is feasible and safe. The procedure is well tolerated, with few major adverse cardiac events at 1 year, and without complications directly related to gene expression. In this prospective, nonblinded study, the procedure is associated with clinical improvement; however, there was no angiographic evidence of angiogenesis and there is a great potential for a sham or placebo effect in the study patients. A randomized phase III trial is underway that will help determine the efficacy of vascular endothelial growth factor-2 gene transfer in “no-option” patients.
