Author/Authors :
Ueland، نويسنده , , Thor and Sikkeland، نويسنده , , Liv I and Yndestad، نويسنده , , Arne and Eiken، نويسنده , , Hans G and Holm، نويسنده , , Torbjّrn and Guevara، نويسنده , , Cecilia and Haug، نويسنده , , Terje and Endresen، نويسنده , , Knut and Frّland، نويسنده , , Stig S and Gullestad MD، نويسنده , , Lars and Andreassen، نويسنده , , Arne K and Geiran، نويسنده , , Odd and Simonsen، نويسنده , , Svein and Aukrus، نويسنده ,
Abstract :
Long-term success of cardiac transplantation is mainly limited by the development of transplant coronary artery disease (CAD); it is generally accepted that it is immune mediated, involving cytokines and growth factors. We show that development of transplant CAD is associated with a particular cytokine profile in myocardial biopsies characterized by a late (i.e., 1 year) increase in tumor necrosis factor-α and interferon-γ gene expression, which precede and potentially contribute to the development of allograft vasculopathy, further supporting a role for inflammation and the pathogenesis of transplant CAD in humans.
