Author/Authors :
Kajinami، نويسنده , , Kouji and Takekoshi، نويسنده , , Noboru and Matsui، نويسنده , , Shinobu and Kanemitsu، نويسنده , , Seiyu and Okubo، نويسنده , , Shinji and Kanayama، نويسنده , , Sugako and Yamashita، نويسنده , , Naohiro and Sato، نويسنده , , Ryoko، نويسنده ,
Abstract :
To find the clinical variables associated with atorvastatinʹs effects on bone metabolism markers, 35 patients with heterozygous familial hypercholesterolemia were treated with atorvastatin for 24 weeks, and the levels of bone formation markers (bone-specific alkaline phosphatase and osteocalcin) and resorption marker (urine collagen type-1 cross-linked N-telopeptide) were determined. Pretreatment vitamin D levels showed significant and positive associations with changes in 2 bone formation markers. The serial changes in 3 markers were favorable—increased bone formation markers and unchanged bone resorption marker—but the changes occurred only in patients with pretreatment vitamin D levels >50 pg/ml.
