Title of article :
Effect of oral l-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries
Author/Authors :
Palloshi، نويسنده , , Altin and Fragasso، نويسنده , , Gabriele and Piatti، نويسنده , , PierMarco and Monti، نويسنده , , Lucilla D. and Setola، نويسنده , , Emanuela and Valsecchi، نويسنده , , Giampiero and Galluccio، نويسنده , , Elena and Chierchia، نويسنده , , Sergio L. and Margonato، نويسنده , , Alberto، نويسنده ,
Abstract :
Thirteen hypertensive patients with microvascular angina were studied before and after receiving oral l-arginine (4 weeks, 2 g, 3 times daily). l-arginine significantly improved angina class, systolic blood pressure at rest, and quality of life. Maximal forearm blood flow, plasma l-arginine, l-arginine:asymmetric dimethyl arginine ratio, and cyclic guanylate monophosphate increased significantly after treatment. In medically treated hypertensive patients with micro-vascular angina, oral l-arginine may represent a useful therapeutic option.
