Author/Authors :
Hermida، نويسنده , , Jean-Sylvain and Jandaud، نويسنده , , Serge and Lemoine، نويسنده , , Jean-Luc and Rodriguez-Lafrasse، نويسنده , , Claire and Delonca، نويسنده , , Jean and Bertrand، نويسنده , , Cathy and Jarry، نويسنده , , Geneviève and Rochette، نويسنده , , Jacques and Rey، نويسنده , , Jean-Luc، نويسنده ,
Abstract :
To determine the prevalence of drug-induced Brugadaʹs syndrome (BrS) electrocardiograms (ECGs) in a healthy population, a sodium channel blockade challenge was performed in previously identified subjects with BrS-compatible (BrC) ECGs. These subjects were detected in 1,000 normal patients in whom first ECGs were systematically recorded. Because of the intermittent nature of electrocardiographic modifications in BrS, second ECGs were also recorded in a representative sample of the population presenting with first ECGs with normal results. The prevalence of typical drug-induced BrS ECGs was 5 of the 1,000 patients. This value was fivefold greater than the reported prevalence of spontaneous BrS ECGs in the healthy population.
