Author/Authors :
Gokce، نويسنده , , Noyan and Vita، نويسنده , , Joseph A. and McDonnell، نويسنده , , Marie and Forse، نويسنده , , Armour R. and Istfan، نويسنده , , Nawfal and Stoeckl، نويسنده , , Maria and Lipinska، نويسنده , , Izabella and Keaney Jr، نويسنده , , John F. and Apovian، نويسنده , , Caroline M.، نويسنده ,
Abstract :
We prospectively examined brachial artery endothelial function using vascular ultrasound in 41 obese subjects treated with medical or surgical (gastric bypass) weight loss interventions. Surgical intervention produced greater weight loss and more pronounced improvement in endothelial function than medical treatment alone. Improved endothelial function with weight loss correlated strongly with fasting glucose but not with alteration in blood pressure, lipids, degree of weight loss, or plasma resistin concentrations. These data demonstrate that weight loss in markedly obese patients improves endothelial function and glycemic control that may represent important mechanisms of the cardiovascular benefit associated with weight reduction.
