Author/Authors :
Gluckman، نويسنده , , Tyler J. and Segal، نويسنده , , Jodi B. and Fredde، نويسنده , , Natalie L. and Saland، نويسنده , , Kenneth E. and Jani، نويسنده , , Jayesh T. and Walenga، نويسنده , , Jeanine M. and Prechel، نويسنده , , M. Margaret and Citro، نويسنده , , Kathleen M. and Zidar، نويسنده , , David A. and Fox، نويسنده , , Emily and Schulman، نويسنده , , Steven P. and Kickler، نويسنده , , Thomas ، نويسنده ,
Abstract :
The incidence of antiplatelet factor-4/heparin antibody formation in patients who receive contemporary doses of unfractionated heparin in the setting of percutaneous coronary revascularization is unknown. Also unknown is the ability of these antibodies to activate platelets or adversely affect clinical outcome in the absence of clinically recognized heparin-induced thrombocytopenia. To address these questions, we serially measured antiplatelet factor-4/heparin antibody levels and performed serotonin release assays in patients who underwent percutaneous coronary intervention. Correlations were then made across antibody induction, heparin exposure, and clinical outcome at 6 months.
