Author/Authors :
Ravn، نويسنده , , Lasse S. and Hofman-Bang، نويسنده , , Jacob and Dixen، نويسنده , , Ulrik and Larsen، نويسنده , , Severin Olesen and Jensen، نويسنده , , Gorm and Haunsّ، نويسنده , , Stig and Svendsen، نويسنده , , Jesper Hastrup and Christiansen، نويسنده , , Michael، نويسنده ,
Abstract :
The 97T polymorphism of the KCNE5 gene, coding for an inhibitory β-subunit, MiRP4, of the repolarizing cardiac potassium ion channel KCNQ1, was significantly more frequent in 96 controls than in 158 patients with atrial fibrillation (AF). KCNQ1 is involved in cardiac action potential, and increased function has been associated with AF. Because the KCNE5 gene is located on the X chromosome, the protection conferred by the 97T polymorphism may help explain the gender-related difference in the risk of AF.
