Author/Authors :
Yamashita، نويسنده , , Atsushi and Sumi، نويسنده , , Takahiro and Goto MD، نويسنده , , Shinya and Hoshiba، نويسنده , , Yasunari and Nishihira، نويسنده , , Kensaku and Kawamoto، نويسنده , , Riichirou and Hatakeyama، نويسنده , , Kinta and Date، نويسنده , , Haruhiko and Imamura، نويسنده , , Takuroh and Ogawa، نويسنده , , Hisao and Asada، نويسنده , , Yujiro، نويسنده ,
Abstract :
The rapid closure of coronary arteries due to occlusive thrombi is the major cause of acute myocardial infarction. However, the mechanisms of coronary thrombus formation have not been elucidated. We immunohistochemically assessed the localizations and their changes over time of glycoprotein IIb/IIIa, fibrin, von Willebrand factor (vWF), and tissue factor (TF), after the onset of chest pain (<4, 4 to 6, or 6 to 12 hours), in fresh coronary thrombi causing acute myocardial infarction. The occlusive thrombi were consistently composed of platelets, fibrin, vWF, and TF from the early phase of onset, and glycoprotein IIb/IIIa and fibrin were closely associated with vWF and TF, respectively. vWF and/or TF may contribute to occlusive thrombus formation and be novel therapeutic candidates for treating patients with coronary thrombosis.
