Author/Authors :
Lofiego، نويسنده , , Carla and Biagini، نويسنده , , Elena and Ferlito، نويسنده , , Marinella and Pasquale، نويسنده , , Ferdinando and Rocchi، نويسنده , , Guido and Perugini، نويسنده , , Enrica and Leone، نويسنده , , Ornella and Bracchetti، نويسنده , , Giovanni and Caliskan، نويسنده , , Kadir and Branzi، نويسنده , , Angelo and ten Cate، نويسنده , , Folkert J. and Rapezzi، نويسنده , , Claudio، نويسنده ,
Abstract :
The pathophysiologic mechanisms of left ventricular (LV) dysfunction in isolated ventricular noncompaction (IVNC) remain unclear. Evaluating global and segmental systolic LV function in 65 patients with IVNC, this study found that normal wall motion was more common in noncompacted than in compacted segments. The number of noncompacted segments per patient correlated positively with the LV ejection fraction and negatively with LV end-diastolic volume index. These paradoxical findings support the concept that noncompaction represents a marker of a more generalized (cardio)myopathy rather than the direct pathophysiologic substrate of this still little-understood disease.
