Author/Authors :
Yazdanpanah، نويسنده , , Mojgan and Rietveld، نويسنده , , Ingrid and Janssen، نويسنده , , Joop A.M.J.L. and Njajou، نويسنده , , Omer T. and Hofman، نويسنده , , Albert and Stijnen، نويسنده , , Theo and Pols، نويسنده , , Huibert A.P. and Lamberts، نويسنده , , Steven W.J. and Witteman، نويسنده , , Jacqueline C.M and van Duijn، نويسنده , , Cornelia M.، نويسنده ,
Abstract :
We investigated whether an insulin-like growth factor I (IGF-I) promoter polymorphism is associated with excess mortality in elderly subjects with myocardial infarction (MI). This association was assessed in 7,983 subjects of the Rotterdam Study during 14 years of follow-up. Among 345 subjects who developed a MI, the risk of mortality was 1.49 times higher in the variant carriers of the IGF-I promoter polymorphism than in the nonvariant carriers (95% confidence interval 1.10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI.
