Transthoracic Echocardiographic Parameters in the Estimation of Pulmonary Capillary Wedge Pressure in Patients With Present or Previous Heart Failure

Multiple echocardiographic criteria are routinely used for the estimation of left heart filling pressures. We assessed the predictive value of various echocardiographic parameters to estimate the left heart filling pressure and proposed a simplified approach for its evaluation. We collected the clinical, echocardiographic, and invasive hemodynamic data from 93 patients with heart failure who underwent right-sided heart catheterization and transthoracic echocardiography within a 24-hour period. Of these 93 patients, 57% had a left ventricular ejection fraction <50% and 69% had an elevated mean pulmonary capillary wedge pressure of ≥15 mm Hg. A mitral E/E′ of ≥15 had a sensitivity of 55% but a specificity of 96%. A left atrial area of ≥20 cm2 had a sensitivity of 66% and specificity of 89%. A deceleration time <140 ms had a sensitivity of 51% and specificity of 93% to predict a pulmonary capillary wedge pressure of ≥15 mm Hg. The combination of E/E′ ≥15 ± left atrial area of ≥20 cm2 ± deceleration time <140 ms provided a sensitivity of 92% and specificity of 85%. On multivariate analysis, the combination of E/E′ ≥15, left atrial area of ≥20 cm2, and deceleration time <140 ms was the most significant predictor of a pulmonary capillary wedge pressure of ≥15 mm Hg (odds ratio 48, 95% confidence interval 10 to 289, p <0.001). In conclusion, this simplified approach using 3 echocardiographic parameters provides an accurate and a practical approach for the routine estimation of the elevated left heart filling pressure.