Author/Authors :
Imamura، نويسنده , , Sari and Hirata، نويسنده , , Kumiko and Orii، نويسنده , , Makoto and Shimamura، نويسنده , , Kunihiro and Shiono، نويسنده , , Yasutsugu and Ishibashi، نويسنده , , Kohei and Tanimoto، نويسنده , , Takashi and Yamano، نويسنده , , Takashi and Ino، نويسنده , , Yasushi and Kitabata، نويسنده , , Hironori and Yamaguchi، نويسنده , , Tomoyuki and Kubo، نويسنده , , Takashi and Tanaka، نويسنده , , Atsushi and Imanishi، نويسنده , , Toshio and Akasaka، نويسنده , , Takashi، نويسنده ,
Abstract :
The relation between albuminuria and coronary microvascular function in patients with chronic kidney disease (CKD) has not been fully investigated. Therefore, we sought to assess whether albuminuria is associated with coronary flow velocity reserve (CFVR) impairment in patients with CKD. Coronary flow study was prospectively performed in 175 patients with CKD. CFVR of the left anterior descending artery was measured to evaluate coronary microvascular function using transthoracic echocardiography. We divided the patients into 5 groups according to the stages of CKD and analyzed the effect of albuminuria. CFVR gradually decreased with an increase in CKD stages. CFVR in patients with albuminuria was lower than those without albuminuria. In groups with CKD stages 2 and 3, the patients with albuminuria showed lower CFVR than those without albuminuria. Multiple logistic regression analysis revealed that albuminuria, age, and gender were independently associated with CFVR impairment. Of these factors, albuminuria was the most powerful predictor with the risk ratio of 12.4 for CFVR impairment. In conclusion, the more the CKD stages progressed, the more severe CFVR was impaired. Albuminuria was associated with CFVR impairment in patients with CKD; even in mild-to-moderate CKD, patients with albuminuria showed further reduced coronary vasodilator capacity.
