Title of article
A possible mechanism for pressure reversal of general anaesthetics from molecular simulations
Author/Authors
Chau، نويسنده , , P.-L. and Hoang، نويسنده , , Paul N.M. and Picaud، نويسنده , , Sylvain and Jedlovszky، نويسنده , , Pلl، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
4
From page
294
To page
297
Abstract
The effect of general anaesthetics is pressure-dependent. We have simulated a fully hydrated dimyristoylphosphatidylcholine bilayer with halothane (a general anaesthetic) embedded, at pressures of 1, 200 and 400 atm, respectively. We find that at higher pressures, halothane molecules tend to cluster together. Based on these results, we propose a possible mechanisms for pressure reversal of anaesthesia.
Journal title
Chemical Physics Letters
Serial Year
2007
Journal title
Chemical Physics Letters
Record number
1921638
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