Addressable high-information-density DNA nanostructures

We present a strategy for self-assembly of the smallest yet reported DNA nanostructures that are also addressable in terms of their DNA-base code. Using linear as well as novel branched three-way DNA oligonucleotide building-blocks we demonstrate the formation of a nano-network’s fundamental cell, a DNA pseudo-hexagon of side 4 nm. The network’s inherent addressability will allow functionalization with sub-nanometer precision yielding unprecedented richness in information density, important in the context of Moore’s Law and nano-chip technology.