Author/Authors :
Xu، نويسنده , , Jianxun and Yudasaka، نويسنده , , Masako and Kouraba، نويسنده , , Sachio and Sekido، نويسنده , , Mitsuru and Yamamoto، نويسنده , , Yuhei and Iijima، نويسنده , , Sumio، نويسنده ,
Abstract :
A single wall carbon nanohorn (SWNH) is a new kind of single-graphene tubules with a diameter of 2–5 nm and a length 40–50 nm. In this work, we used oxidized SWNH (SWNHox) to incorporate vancomycin hydrochloride (VCM) for its controlled release by taking advantage of the interactions between VCM and SWNHox. Phospholipid–poly(ethylene glycol) was used to modify the hydrophobic surface of SWNHox to improve its dispersion in aqueous systems. In the release study using this complex, a stable release of VCM was achieved for an extended period.
