Solvent suppression without crosspeak attenuation in iZQC experiments

The observation of solvent–solute iZQC peaks is often hampered by strong nearby solvent peaks. Previous researchers have overcome this problem by adding conventional solvent suppression modules during the dipolar evolution time. Here we show that these solvent suppression modules refocus the dipolar field and lead to a substantial signal intensity reduction, which is particularly damaging for the detection of low concentration species. We analyze, in detail, the effect of such modules on the signal formation, and demonstrate a method for solvent suppression that does not interfere with dipolar field evolution, leading to cleaner spectra.