Title of article :
Carbon nanotube-gelatin-hydroxyapatite nanohybrids with multilayer core–shell structure for mimicking natural bone
Author/Authors :
Yoon، نويسنده , , Il-Kyu and Hwang، نويسنده , , Jiyoung and Seo، نويسنده , , Jae-won and Jang، نويسنده , , Won-Cheoul and Kim، نويسنده , , Haewon and Shin، نويسنده , , Ueon Sang، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
We attempted to mimic collagen fibrils bearing apatite crystals in natural bone, using gelatin, carboxylic acid functionalized carbon nanotubes (f-CNTs), and hydroxyapatite (HA). Gelatin molecules were covalently grafted on the surface of f-CNTs by the formation of amide linkages. HA crystals were then assembled onto the gelatin-grafted f-CNTs in a highly concentrated CaP solution, resulting a multilayered core–shell structure, consisting of a f-CNT core and gelatin-HA shells (as a fibrous multilayered f-CNT/Gel/HA nanohybrid), and in a similar formation to the collagen fibers of natural bone. The tensile strength, elastic modulus, and elongation rate of the new hybrid material were significantly improved compared to both pure (f-CNT free) gelatin and a mixture of f-CNT and gelatin, by 4.6–8.8, 9–10, and 28–42 times, respectively. Cell viability studies of the f-CNT/Gel/HA nanohybrid also suggest a higher degree of biocompatibility compared to pure gelatin.