Formation of extended probe–cyclodextrin nanotubular supra structures: Endogenous surfactants triggered on-demand release

Steady state absorption, emission, and picosecond time resolved fluorescence and transmission electron microscopic (TEM) techniques have been exploited to substantiate and characterize the formation of a substrate—anchored β-cyclodextrin nanotubular suprastructure in aqueous medium. Experimental results reveal that suprastructure is originated from a purely ground state interaction between a newly developed bisindole based drug molecule namely 3,3′-bis(indolyl)-4-chlorophenylmethane (BICPM) with β-cyclodextrin. The bound drug molecule is susceptible to be released out from the supramolecular complex in a controlled manner by the use of endogenous surfactants and is poised to serve a significant purpose in targeted drug delivery preferably at the intestinal region.