Parenteral nanosuspension of a novel synthesized antitumor candidate: Investigation of tissue biodistributions and plasma pharmacokinetics

Previously, nanosuspension of a novel synthesized p-terphenyl derivative (H2, ) with a mean particle size of 201.7 ± 5.87 nm was prepared using precipitation–microfluidization method. Enhanced saturation solubility and accelerated dissolution velocity were achieved. The objectives of this current study were to investigate the tissue biodistribution and plasma pharmacokinetic properties of H2 nanosuspension comparing with that of H2 solution after intravenously administration to mice. In an attempt to ensure the drug content accuracy during the animal tests, chemical stability of H2 nanosuspension was also monitored over a 1 month period. As shown in the plasma concentration–time profiles, drug nanosuspensions were effective in increasing the plasma level of H2 compared to drug solution. In particular, the initial concentration of H2 administered as nanosuspension and solution were 13.05 μg/mL and 5.54 μg/mL, respectively. Whatʹs more, compared with H2 solution, nanosuspension significantly changed drug biodistribution features in tissues, relatively increased drug concentration in liver and lung, and decreased that in other tissues.