Tunable plasma lipoprotein uptake/transport across the blood–brain barrier

Brain development and maintenance requires transportation of cerebral sustenance across the blood–brain barrier. Disorders of this process can induce neurodegenerative diseases, which can affect numerous patients and incur significant treatment expenses. Recent scientific advances suggest that knowledge of this transportation will lead to the development of tailor-made theranostic strategies. Biotechnological tools such as biocompatible nanoparticles have promising potential in this context, however, information about their consequences in the brain is largely unknown. The present study demonstrates the application of specifically constructed cerebral sustenance nanoparticles in the form of tunable plasma lipoproteins to provide information about their pathways to the brain and delivery to glia cells. Individual cell analysis in brain sections enabled us to understand the accumulation of tunable plasma lipoproteins in the cerebral cortex, striatum, and cerebellum, which have been previously identified as the incident regions of Alzheimerʹs disease, Parkinsonʹs disease, and spinocerebellar ataxia. The adjustability of the tunable plasma lipoproteins enables their use in theranostic applications against neurodegenerative diseases.