Sulfamate sweeteners

After a short introduction to the subject of sulfamate (cyclamate) sweeteners, recent work on structure-taste aspects is reviewed. Some revisitation to well known classes, such as the heterosulfamates and the disubstituted aromatic sulfamates, is made and updates are provided. Several entirely new and novel types of sulfamates including carbinyl sulfamates (ureasulfonates) (I), sulfonyl sulfamates (sulfonamide sulfonates) (II), sulfamidyl sulfamates (sulfamide sulfonates) (III) and iminyl sulfamates (hydrazonyl sulfonates) (IV) are introduced. y, the development of QSARs for sweet sulfamates is discussed, using a data base of 20 different sulfamates of widely varying structural types and having a relative sweetness (RS) spread of over 100.