Author/Authors :
Liu، نويسنده , , Jie and Shimizu، نويسنده , , Kuniyoshi and Konishi، نويسنده , , Fumiko and Noda، نويسنده , , Kiyoshi and Kumamoto، نويسنده , , Shoichiro and Kurashiki، نويسنده , , Kenji and Kondo، نويسنده , , Ryuichiro، نويسنده ,
Abstract :
The ethanol extract of Ganoderma lucidum showed inhibitory activity on both isozymes (types 1 and 2) of 5α-reductase and suppression effects of ventral prostate growth induced by testosterone in castrated rat, but not induced by dihydrotestosterone. Activity-guided fractionation and TLC analysis suggested that the active principles in vivo were triterpenoids. These results indicate that the triterpenoids fraction of G. lucidum might be a useful ingredient in the treatment of benign prostatic hyperplasia.
Keywords :
Anti-androgen activities , Triterpenoid , Ganoderma lucidum , 5?-Reductase , Benign Prostatic Hyperplasia
