Nolomirole (CHF 1035): Polymorph detection from FT-Raman analysis

FT-Raman spectra (λexc=1064 nm) of two crystalline forms (I and II) of Nolomirole are presented and discussed. Spectral markers characteristic and selective for the two polymorphs are identified. The analysis of Raman spectra obtained from samples made as mechanical mixtures of the two pure polymorphs suggests criteria for developing a spectroscopic method for the determination of the two phases in Nolomirole samples of unknown polymorph composition. s basis a revision of some published results and conclusions concerning phase transformations occurring in thermally and/or mechanically treated Nolomirole powders is proposed.