The electrochemical oxidation of troxerutin and its sensitive determination in pharmaceutical dosage forms at PVP modified carbon paste electrode

The voltammetric responses of troxerutin were investigated at polyvinylpyrrolidone (cross-linked) (PVP) modified carbon paste electrode (CPE) in 0.1 mol/L KCl by several electrochemical techniques. A well-defined oxidation peak was observed at about 0.97 V. Compared with poor responses of troxerutin at bare electrode that at this modified electrode has been greatly improved. It is PVP that enhances the adsorption of troxerutin to electrode surface based on their hydrophobic property. Under some optimized experimental conditions, a simple and sensitive electroanalytical method was developed for the quantitative analysis of troxerutin. A very low detection limit of 5.0 × 10−9 mol/L was obtained for 5 min accumulation at open circuit (S/N = 3). This proposed method was successfully applied to the detection of troxerutin in pharmaceutical dosage forms and satisfying results had been obtained.